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Therefore, in the setting of total hip replacement, preoperative receipt of a hip injection may increase the risk of infection, leading to early revision arthroplasty. While the researchers were unable to determine what agent was injected into the joint prior to surgery, they concluded that the most likely therapies were corticosteroids and hyaluronic acid, with or without a local anesthetic. As hyaluronic acid has no proven benefit for hip osteoarthritis, it is likely that most of the injections were of corticosteroids. Corticosteroid joint injection may have local immunomodulatory effects that may increase the risk of infection following hip replacement. If so, there may be a period of time required for these effects to be ‘cleared’ before a hip replacement can be safely implanted into the joint. 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